Research Interests

My research interests are in the area of synthetic organic chemistry with applications to the design and synthesis of small organic molecules to address malaria as well as other tropical diseases. Currently, my interests are focused on two projects; one aimed at exploring the inhibition of the enzyme farnesyltransferase and its effect on malaria. The second, which is in the initial stages, involves a collaboration with Dr. David Sullivan at John Hopkins School of Medicine exploring treatments for malaria using small molecules that Dr. Sullivan identified with activity on the Plasmodium falciparum in a screen of a library of known drug molecules.

Publications

Synthesis of Novel Imidazoline Containing Octopaminergic Analogues Elshenawy, Z. M.; Wendt, H. R.; Dixson, J.A.; H. R; Eldridge, J. R.; Lyga, J. W.; Seghel, S.; Argentine, J. A; Henrie II, R. H.; Roush, D. M.; Yeager, W.; Donovan, S.; Suarez, D.; Ding, P.; Dargar, R.; Chaguturu, R.; ACS Mid Atlantic Regional Meeting, Hersey, Pennsylvania, 4-7 June 2006.

Synthetic Approaches to Tetrahydroquinoline Ecdysone Agonists Dixson, J.A.; Elshenawy, Z. E.; Chiu, G.; Wyle, M. J.; Eldridge, J. R.; Dungan, L. B.; Wowkun, G.S. (Invited Speaker) Seventh Florida Heterocycles Conference, University of Florida, Gainesville, Florida; March 2006

A New Class of Potent Ecdysone Agonists: 4-Phenylamino-1,2,3,4-Tetrahydroquinolines. Dixson, J.A.; Elshenawy, Z. M.; Eldridge, J. R.; Dungan, L.B.; Chiu, G.; Wowkun, G. S.; Wyle, M. J.; ACS Mid Atlantic Regional Meeting, Newark, Delaware, 15-16-May 2000. (presentation)

2,4-Diaminoquinazoline insecticides. Rowley, Elizabeth G.; Cullen, Thomas G.; Dixson, John A.; ElMarakby, Sayed; LaFrance, Louis V.; Sehgel, Saroj; Warkentin, Dennis. Agricultural Products Group, FMC Corporation, Princeton, NJ, USA. ACS Symposium Series (2007), 948(Synthesis and Chemistry of Agrochemicals VII), 167-176. American Chemical Society.

Preparation of insecticidal 5-bis(methoxymethyl)aminopyrazole derivatives. Zydowsky, Thomas; Ali, Syed F.; Yeager, Walter H.; Lyga, John W.; Dixson, John A.; Donovan, Stephen F.; Theodoridis, George. (FMC Corporation, USA). PCT Int. Appl. (2006), WO2006138148 A1

Preparation of insecticidal and acaricidal substituted benzylamino heterocyclic and heteroaryl derivatives. Dixson, John A.; Theodoridis, George; Elshenawy, Zeinab M.; Dugan, Benjamin J.; Patel, Manorama M.; Barron, Edward J.; Donovan, Stephen F. (FMC Corporation, USA). PCT Int. Appl. (2006), WO 2006127426 A2.